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However, the exact mechanism of ferroptosis remains unclear (Feng and Stockwell 2018)

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

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Consistent with the role of cholesterol in the regulation of membrane dynamics, cholesterol loading in mitochondrial membrane results in increased membrane order parameter and in the reduction in the activity of specific membrane carriers, i B via c-SRC and oxidant-dependent cell death

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In contrast to BMAL1 expression in the lens, CLOCK expression did not fluctuate over the 24-hour period ( Figure 3B ) and the subcellular localisation of CLOCK remained nuclear during the light vs dark period ( Figures 5EH, EH )